53BP1 Mediates the Fusion of Mammalian Telomeres Rendered Dysfunctional by DNA-PKcs Loss or Inhibition

Telomere dysfunction promotes genomic instability and carcinogenesis via inappropriate end-to-end chromosomal rearrangements, or telomere fusions. Previous work indicates that the DNA Damage Response (DDR) factor 53BP1 promotes the fusion of telomeres rendered dysfunctional by loss of TRF2, but is d...

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Detalles Bibliográficos
Autores principales: Rybanska-Spaeder, Ivana, Ghosh, Rajib, Franco, Sonia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181871/
https://www.ncbi.nlm.nih.gov/pubmed/25264618
http://dx.doi.org/10.1371/journal.pone.0108731

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4181871/
https://www.ncbi.nlm.nih.gov/pubmed/25264618
http://dx.doi.org/10.1371/journal.pone.0108731

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