Design, synthesis and SAR exploration of tri-substituted 1,2,4-triazoles as inhibitors of the annexin A2–S100A10 protein interaction

Recent target validation studies have shown that inhibition of the protein interaction between annexin A2 and the S100A10 protein may have potential therapeutic benefits in cancer. Virtual screening identified certain 3,4,5-trisubstituted 4H-1,2,4-triazoles as moderately potent inhibitors of this in...

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Detalles Bibliográficos
Autores principales: Reddy, Tummala R.K., Li, Chan, Guo, Xiaoxia, Fischer, Peter M., Dekker, Lodewijk V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182301/
https://www.ncbi.nlm.nih.gov/pubmed/25172147
http://dx.doi.org/10.1016/j.bmc.2014.07.043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182301/
https://www.ncbi.nlm.nih.gov/pubmed/25172147
http://dx.doi.org/10.1016/j.bmc.2014.07.043

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