Synthesis and Characterization of Novel 2-Amino-Chromene-Nitriles that Target Bcl-2 in Acute Myeloid Leukemia Cell Lines

The anti-apoptotic protein Bcl-2 is a well-known and attractive therapeutic target for cancer. In the present study the solution-phase T3P-DMSO mediated efficient synthesis of 2-amino-chromene-3-carbonitriles from alcohols, malanonitrile and phenols is reported. These novel 2-amino-chromene-3-carbon...

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Detalles Bibliográficos
Autores principales: Keerthy, Hosadurga K., Garg, Manoj, Mohan, Chakrabhavi D., Madan, Vikas, Kanojia, Deepika, Shobith, Rangappa, Nanjundaswamy, Shivananju, Mason, Daniel J., Bender, Andreas, Basappa, Rangappa, Kanchugarakoppal S., Koeffler, H. Phillip
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182326/
https://www.ncbi.nlm.nih.gov/pubmed/25268519
http://dx.doi.org/10.1371/journal.pone.0107118

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182326/
https://www.ncbi.nlm.nih.gov/pubmed/25268519
http://dx.doi.org/10.1371/journal.pone.0107118

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