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In Silico, Experimental, Mechanistic Model for Extended-Release Felodipine Disposition Exhibiting Complex Absorption and a Highly Variable Food Interaction

The objective of this study was to develop and explore new, in silico experimental methods for deciphering complex, highly variable absorption and food interaction pharmacokinetics observed for a modified-release drug product. Toward that aim, we constructed an executable software analog of study pa...

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Detalles Bibliográficos
Autores principales: Kim, Sean H. J., Jackson, Andre J., Hunt, C. Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182452/
https://www.ncbi.nlm.nih.gov/pubmed/25268237
http://dx.doi.org/10.1371/journal.pone.0108392