The Indolinone MAZ51 Induces Cell Rounding and G2/M Cell Cycle Arrest in Glioma Cells without the Inhibition of VEGFR-3 Phosphorylation: Involvement of the RhoA and Akt/GSK3β Signaling Pathways

MAZ51 is an indolinone-based molecule originally synthesized as a selective inhibitor of vascular endothelial growth factor receptor (VEGFR)-3 tyrosine kinase. This study shows that exposure of two glioma cell lines, rat C6 and human U251MG, to MAZ51 caused dramatic shape changes, including the retr...

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Detalles Bibliográficos
Autores principales: Park, Joo-Hee, Shin, Yoo-Jin, Riew, Tae-Ryong, Lee, Mun-Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182637/
https://www.ncbi.nlm.nih.gov/pubmed/25268128
http://dx.doi.org/10.1371/journal.pone.0109055

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182637/
https://www.ncbi.nlm.nih.gov/pubmed/25268128
http://dx.doi.org/10.1371/journal.pone.0109055

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