MiR-410 Is Overexpressed in Liver and Colorectal Tumors and Enhances Tumor Cell Growth by Silencing FHL1 via a Direct/Indirect Mechanism

FHL1 is an important tumor-suppressor that is downregulated in multiple tumors by unknown mechanisms. We demonstrated that miR-410 specifically targets the 3′UTR of FHL1. Furthermore, using DNA bisulfite modification and sequencing experiments, we demonstrated that the FHL1 promoter is hypermethylat...

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Detalles Bibliográficos
Autores principales: Wang, Yu, Fu, Jie, Jiang, Mengmeng, Zhang, Xiaoai, Cheng, Long, Xu, Xiaojie, Fan, Zhongyi, Zhang, Jing, Ye, Qinong, Song, Haifeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182719/
https://www.ncbi.nlm.nih.gov/pubmed/25272045
http://dx.doi.org/10.1371/journal.pone.0108708

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182719/
https://www.ncbi.nlm.nih.gov/pubmed/25272045
http://dx.doi.org/10.1371/journal.pone.0108708

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