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Mechanism of the Exchange Reaction in HRAS from Multiscale Modeling
HRAS regulates cell growth promoting signaling processes by cycling between active (GTP-bound) and inactive (GDP-bound) states. Understanding the transition mechanism is central for the design of small molecules to inhibit the formation of RAS-driven tumors. Using a multiscale approach involving coa...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182752/ https://www.ncbi.nlm.nih.gov/pubmed/25272152 http://dx.doi.org/10.1371/journal.pone.0108846 |