Gabapentin reverses central hypersensitivity and suppresses medial prefrontal cortical glucose metabolism in rats with neuropathic pain

BACKGROUND: Gabapentin (GBP) is known to suppress neuropathic hypersensitivity of primary afferents and the spinal cord dorsal horn. However, its supra-spinal action sites are unclear. We identify the brain regions where GBP changes the brain glucose metabolic rate at the effective dose that allevia...

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Detalles Bibliográficos
Autores principales: Lin, Hsiao-Chun, Huang, Yu-Hsin, Chao, Tzu-Hao Harry, Lin, Wen-Ying, Sun, Wei-Zen, Yen, Chen-Tung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182821/
https://www.ncbi.nlm.nih.gov/pubmed/25253440
http://dx.doi.org/10.1186/1744-8069-10-63

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182821/
https://www.ncbi.nlm.nih.gov/pubmed/25253440
http://dx.doi.org/10.1186/1744-8069-10-63

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