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Hemizygous Le-Cre Transgenic Mice Have Severe Eye Abnormalities on Some Genetic Backgrounds in the Absence of LoxP Sites
Eye phenotypes were investigated in Le-Cre(Tg/−); Pax6(fl/+) mice, which were expected to show tissue-specific reduction of Pax6 in surface ectoderm derivatives. To provide a better comparison with our previous studies of Pax6(+/−) eye phenotypes, hemizygous Le-Cre(Tg/−) and heterozygous Pax6(fl/+)m...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182886/ https://www.ncbi.nlm.nih.gov/pubmed/25272013 http://dx.doi.org/10.1371/journal.pone.0109193 |