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Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces

Many protein-protein interactions (PPIs) are compelling targets for drug discovery, and in a number of cases can be disrupted by small molecules. The main goal of this study is to examine the mechanism of binding site formation in the interface region of proteins that are PPI targets by comparing li...

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Detalles Bibliográficos
Autores principales: Bohnuud, Tanggis, Kozakov, Dima, Vajda, Sandor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183424/
https://www.ncbi.nlm.nih.gov/pubmed/25275445
http://dx.doi.org/10.1371/journal.pcbi.1003872