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Evidence of Conformational Selection Driving the Formation of Ligand Binding Sites in Protein-Protein Interfaces
Many protein-protein interactions (PPIs) are compelling targets for drug discovery, and in a number of cases can be disrupted by small molecules. The main goal of this study is to examine the mechanism of binding site formation in the interface region of proteins that are PPI targets by comparing li...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183424/ https://www.ncbi.nlm.nih.gov/pubmed/25275445 http://dx.doi.org/10.1371/journal.pcbi.1003872 |