Mechanism of Suppression of Chromosomal Instability by DNA Polymerase POLQ

Although a defect in the DNA polymerase POLQ leads to ionizing radiation sensitivity in mammalian cells, the relevant enzymatic pathway has not been identified. Here we define the specific mechanism by which POLQ restricts harmful DNA instability. Our experiments show that Polq-null murine cells are...

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Detalles Bibliográficos
Autores principales: Yousefzadeh, Matthew J., Wyatt, David W., Takata, Kei-ichi, Mu, Yunxiang, Hensley, Sean C., Tomida, Junya, Bylund, Göran O., Doublié, Sylvie, Johansson, Erik, Ramsden, Dale A., McBride, Kevin M., Wood, Richard D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183433/
https://www.ncbi.nlm.nih.gov/pubmed/25275444
http://dx.doi.org/10.1371/journal.pgen.1004654

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183433/
https://www.ncbi.nlm.nih.gov/pubmed/25275444
http://dx.doi.org/10.1371/journal.pgen.1004654

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