Cargando…

EGFR has a tumor-promoting role in liver macrophages during hepatocellular carcinoma formation

Hepatocellular carcinoma (HCC) is a frequent cancer with limited treatment options and poor prognosis. Tumorigenesis has been linked with macrophage-mediated chronic inflammation and diverse signaling pathways including the Epidermal Growth Factor Receptor (EGFR) pathway. The precise role of EGFR in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lanaya, Hanane, Natarajan, Anuradha, Komposch, Karin, Li, Liang, Amberg, Nicole, Chen, Lei, Wculek, Stefanie K., Hammer, Martina, Zenz, Rainer, Peck-Radosavljevic, Markus, Sieghart, Wolfgang, Trauner, Michael, Wang, Hongyang, Sibilia, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183558/ https://www.ncbi.nlm.nih.gov/pubmed/25173978 http://dx.doi.org/10.1038/ncb3031

Ejemplares similares

EGFR Signaling in Liver Diseases
por: Komposch, Karin, et al.
Publicado: (2015)

Cancer and liver cirrhosis: implications on prognosis and management
por: Pinter, Matthias, et al.
Publicado: (2016)

The impact of thyroid hormones on patients with hepatocellular carcinoma
por: Pinter, Matthias, et al.
Publicado: (2017)

Oxidative stress mediates an increased formation of vascular endothelial growth factor in human hepatocarcinoma cells exposed to erlotinib
por: Rohr-Udilova, Nataliya, et al.
Publicado: (2017)

Metabolism of tissue macrophages in homeostasis and pathology
por: Wculek, Stefanie K., et al.
Publicado: (2021)

Short- and long-term effects of transarterial chemoembolization on portal hypertension in patients with hepatocellular carcinoma
por: Scheiner, Bernhard, et al.
Publicado: (2019)

EGFR Controls Hair Shaft Differentiation in a p53-Independent Manner
por: Amberg, Nicole, et al.
Publicado: (2019)

Proton Pump Inhibitor Intake neither Predisposes to Spontaneous Bacterial Peritonitis or Other Infections nor Increases Mortality in Patients with Cirrhosis and Ascites
por: Mandorfer, Mattias, et al.
Publicado: (2014)

Neuropilin-2 induced by transforming growth factor-β augments migration of hepatocellular carcinoma cells
por: Wittmann, Philipp, et al.
Publicado: (2015)

Morphometric Analysis of Mast Cells in Tumor Predicts Recurrence of Hepatocellular Carcinoma After Liver Transplantation
por: Rohr‐Udilova, Nataliya, et al.
Publicado: (2021)

Mechanisms underlying skin disorders induced by EGFR inhibitors
por: Holcmann, Martin, et al.
Publicado: (2015)

Transforming Growth Factor‐β and Axl Induce CXCL5 and Neutrophil Recruitment in Hepatocellular Carcinoma
por: Haider, Christine, et al.
Publicado: (2018)

Cancer and hepatic steatosis
por: Paternostro, R., et al.
Publicado: (2021)

An Integrated Care Initiative to Improve Patient Outcome in Schizophrenia
por: Mayer-Amberg, Norbert, et al.
Publicado: (2016)

Transjugular intrahepatic portosystemic shunts (TIPS) for the prevention of variceal re-bleeding – A two decades experience
por: Bucsics, Theresa, et al.
Publicado: (2018)

Drug Therapy for Advanced-Stage Liver Cancer
por: Peck-Radosavljevic, Markus
Publicado: (2014)

Editorial
por: Peck-Radosavljevic, Markus
Publicado: (2020)

Low 25-OH-vitamin D levels reflect hepatic dysfunction and are associated with mortality in patients with liver cirrhosis
por: Paternostro, Rafael, et al.
Publicado: (2016)

Early Neutrophil Responses to Chemical Carcinogenesis Shape Long-Term Lung Cancer Susceptibility
por: Wculek, Stefanie K., et al.
Publicado: (2020)

Erectile dysfunction in cirrhosis is impacted by liver dysfunction, portal hypertension, diabetes and arterial hypertension
por: Paternostro, Rafael, et al.
Publicado: (2018)

Review article: systemic treatment of hepatocellular carcinoma
por: Pinter, Matthias, et al.
Publicado: (2018)

The Amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
por: Raugh, Arielle, et al.
Publicado: (2023)

The amphiregulin/EGFR axis has limited contribution in controlling autoimmune diabetes
por: Raugh, Arielle, et al.
Publicado: (2023)

EGFR in Tumor-Associated Myeloid Cells Promotes Development of Colorectal Cancer in Mice and Associates With Outcomes of Patients
por: Srivatsa, Sriram, et al.
Publicado: (2017)

Metabolic Control of Dendritic Cell Functions: Digesting Information
por: Wculek, Stefanie K., et al.
Publicado: (2019)

Dysbalanced sex hormone status is an independent predictor of decompensation and mortality in patients with liver cirrhosis
por: Paternostro, Rafael, et al.
Publicado: (2018)

Time to stop using hepatic arterial infusion chemotherapy (HAIC) for advanced hepatocellular carcinoma?—the SCOOP-2 trial experience
por: Peck-Radosavljevic, Markus, et al.
Publicado: (2020)

Immunotherapy for advanced hepatocellular carcinoma: a focus on special subgroups
por: Pinter, Matthias, et al.
Publicado: (2021)

EGFR/Ras-induced CCL20 production modulates the tumour microenvironment
por: Hippe, Andreas, et al.
Publicado: (2020)

Programmed cell death protein‐1 (PD‐1)‐targeted immunotherapy in advanced hepatocellular carcinoma: efficacy and safety data from an international multicentre real‐world cohort
por: Scheiner, Bernhard, et al.
Publicado: (2019)

EGFR controls bone development by negatively regulating mTOR-signaling during osteoblast differentiation
por: Linder, Markus, et al.
Publicado: (2018)

Interferon-free regimens improve health-related quality of life and fatigue in HIV/HCV-coinfected patients with advanced liver disease: A retrospective study
por: Scheiner, Bernhard, et al.
Publicado: (2016)

Noninvasive Monitoring of Liver Disease Regression after Hepatitis C Eradication Using Gadoxetic Acid-Enhanced MRI
por: Haider, Lukas, et al.
Publicado: (2018)

Progress in eradication of HCV in HIV positive patients with significant liver fibrosis in Vienna
por: Steiner, Sebastian, et al.
Publicado: (2017)

Correction to: EGFR/Ras-induced CCL20 production modulates the tumour microenvironment
por: Hippe, Andreas, et al.
Publicado: (2021)

Dual inhibition of EGFR and mTOR pathways in small cell lung cancer
por: Schmid, K, et al.
Publicado: (2010)

Non-invasive liver fibrosis assessment and HCV treatment initiation within a systematic screening program in HIV/HCV coinfected patients
por: Chromy, David, et al.
Publicado: (2017)

Impact of patatin‐like phospholipase domain containing 3 rs738409 G/G genotype on hepatic decompensation and mortality in patients with portal hypertension
por: Mandorfer, M., et al.
Publicado: (2018)

EGFR tyrosine kinase activity and Rab GTPases coordinate EGFR trafficking to regulate macrophage activation in sepsis
por: Zhang, Xuedi, et al.
Publicado: (2022)

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen
por: Wculek, Stefanie K., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_racs84460p0vs4e3fbi04nfcqi