Identification of Potent and Selective Non-covalent Inhibitors of the Plasmodium falciparum Proteasome

[Image: see text] We have identified short N,C-capped peptides that selectively inhibit the proteasome of the malaria-causing pathogen Plasmodium falciparum. These compounds are highly potent in culture with no toxicity in host cells. One cyclic biphenyl ether compound inhibited intraerythrocytic gr...

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Detalles Bibliográficos
Autores principales: Li, Hao, Tsu, Christopher, Blackburn, Christopher, Li, Gang, Hales, Paul, Dick, Lawrence, Bogyo, Matthew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183598/
https://www.ncbi.nlm.nih.gov/pubmed/25226494
http://dx.doi.org/10.1021/ja507692y

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183598/
https://www.ncbi.nlm.nih.gov/pubmed/25226494
http://dx.doi.org/10.1021/ja507692y

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