Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds

[Image: see text] 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))–H and C(sp(2))–H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically control...

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Autores principales: Zhu, Ru-Yi, He, Jian, Wang, Xiao-Chen, Yu, Jin-Quan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183600/
https://www.ncbi.nlm.nih.gov/pubmed/25208210
http://dx.doi.org/10.1021/ja508165a
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author Zhu, Ru-Yi
He, Jian
Wang, Xiao-Chen
Yu, Jin-Quan
author_facet Zhu, Ru-Yi
He, Jian
Wang, Xiao-Chen
Yu, Jin-Quan
author_sort Zhu, Ru-Yi
collection PubMed
description [Image: see text] 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))–H and C(sp(2))–H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids.
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spelling pubmed-41836002015-09-10 Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds Zhu, Ru-Yi He, Jian Wang, Xiao-Chen Yu, Jin-Quan J Am Chem Soc [Image: see text] 9-Methylacridine was identified as a generally effective ligand to promote a Pd(II)-catalyzed C(sp(3))–H and C(sp(2))–H alkylation of simple amides with various alkyl iodides. This alkylation reaction was applied to the preparation of unnatural amino acids and geometrically controlled tri- and tetrasubstituted acrylic acids. American Chemical Society 2014-09-10 2014-09-24 /pmc/articles/PMC4183600/ /pubmed/25208210 http://dx.doi.org/10.1021/ja508165a Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Zhu, Ru-Yi
He, Jian
Wang, Xiao-Chen
Yu, Jin-Quan
Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
title Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
title_full Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
title_fullStr Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
title_full_unstemmed Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
title_short Ligand-Promoted Alkylation of C(sp(3))–H and C(sp(2))–H Bonds
title_sort ligand-promoted alkylation of c(sp(3))–h and c(sp(2))–h bonds
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183600/
https://www.ncbi.nlm.nih.gov/pubmed/25208210
http://dx.doi.org/10.1021/ja508165a
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AT wangxiaochen ligandpromotedalkylationofcsp3handcsp2hbonds
AT yujinquan ligandpromotedalkylationofcsp3handcsp2hbonds

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