Strategy for “Detoxification” of a Cancer-Derived Histone Mutant Based on Mapping Its Interaction with the Methyltransferase PRC2

[Image: see text] The histone methyltransferase PRC2 plays a central role in genomic stability and cellular development. Consequently, its misregulation has been implicated in several cancers. Recent work has shown that a histone H3 mutant, where the PRC2 substrate residue Lys27 is replaced by methi...

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Detalles Bibliográficos
Autores principales: Brown, Zachary Z., Müller, Manuel M., Jain, Siddhant U., Allis, C. David, Lewis, Peter W., Muir, Tom W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183613/
https://www.ncbi.nlm.nih.gov/pubmed/25180930
http://dx.doi.org/10.1021/ja5060934

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183613/
https://www.ncbi.nlm.nih.gov/pubmed/25180930
http://dx.doi.org/10.1021/ja5060934

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