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Asymmetric Mannich Synthesis of α-Amino Esters by Anion-Binding Catalysis
[Image: see text] We report a scalable, one-pot Mannich route to enantioenriched α-amino esters by direct reaction of α-chloroglycine ester as a practical imino ester surrogate. The reaction is promoted by a chiral aminothiourea, which is proposed to operate cooperatively by generating an iminium io...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183616/ https://www.ncbi.nlm.nih.gov/pubmed/25178040 http://dx.doi.org/10.1021/ja5075163 |