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Defining the Molecular Basis of Amyloid Inhibitors: Human Islet Amyloid Polypeptide–Insulin Interactions

[Image: see text] Human islet amyloid polypeptide (hIAPP or Amylin) is a 37 residue hormone that is cosecreted with insulin from the pancreatic islets. The aggregation of hIAPP plays a role in the progression of type 2 diabetes and contributes to the failure of islet cell grafts. Despite considerabl...

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Detalles Bibliográficos
Autores principales: Susa, Anna C., Wu, Chun, Bernstein, Summer L., Dupuis, Nicholas F., Wang, Hui, Raleigh, Daniel P., Shea, Joan-Emma, Bowers, Michael T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183647/
https://www.ncbi.nlm.nih.gov/pubmed/25144879
http://dx.doi.org/10.1021/ja504031d