Direct Reprogramming of Huntington’s Disease Patient Fibroblasts into Neuron-Like Cells Leads to Abnormal Neurite Outgrowth, Increased Cell Death, and Aggregate Formation

Recent advances in trans-differentiation of one type cell to another have made it possible to directly convert Huntington’s disease (HD) patient fibroblasts into neurons by modulation of cell-lineage-specific transcription factors or RNA processing. However, this possibility has not been examined. H...

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Detalles Bibliográficos
Autores principales: Liu, Yanying, Xue, Yuanchao, Ridley, Samantha, Zhang, Dong, Rezvani, Khosrow, Fu, Xiang-Dong, Wang, Hongmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183653/
https://www.ncbi.nlm.nih.gov/pubmed/25275533
http://dx.doi.org/10.1371/journal.pone.0109621

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183653/
https://www.ncbi.nlm.nih.gov/pubmed/25275533
http://dx.doi.org/10.1371/journal.pone.0109621

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