The Disaccharide Moiety of Bleomycin Facilitates Uptake by Cancer Cells

[Image: see text] The disaccharide moiety is responsible for the tumor cell targeting properties of bleomycin (BLM). While the aglycon (deglycobleomycin) mediates DNA cleavage in much the same fashion as bleomycin, it exhibits diminished cytotoxicity in comparison to BLM. These findings suggested th...

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Detalles Bibliográficos
Autores principales: Schroeder, Benjamin R., Ghare, M. Imran, Bhattacharya, Chandrabali, Paul, Rakesh, Yu, Zhiqiang, Zaleski, Paul A., Bozeman, Trevor C., Rishel, Michael J., Hecht, Sidney M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183664/
https://www.ncbi.nlm.nih.gov/pubmed/25184545
http://dx.doi.org/10.1021/ja507255g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183664/
https://www.ncbi.nlm.nih.gov/pubmed/25184545
http://dx.doi.org/10.1021/ja507255g

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