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Base-cleavable microarrays for the characterization of DNA and RNA oligonucleotides synthesized in situ by photolithography
Assessing synthesis efficiency, errors, failed deprotections, and chemical and enzymatic degradation of oligonucleotides on microarrays is essential for improving existing in situ synthesis methods, and for the development of new chemistries. We describe the use of LC-MS to analyse DNA and RNA oligo...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4183992/ https://www.ncbi.nlm.nih.gov/pubmed/25213224 http://dx.doi.org/10.1039/c4cc05771f |