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bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
Summary: We present bammds, a practical tool that allows visualization of samples sequenced by second-generation sequencing when compared with a reference panel of individuals (usually genotypes) using a multidimensional scaling algorithm. Our tool is aimed at determining the ancestry of unknown sam...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184259/ https://www.ncbi.nlm.nih.gov/pubmed/24974206 http://dx.doi.org/10.1093/bioinformatics/btu410 |
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author | Malaspinas, Anna-Sapfo Tange, Ole Moreno-Mayar, José Víctor Rasmussen, Morten DeGiorgio, Michael Wang, Yong Valdiosera, Cristina E. Politis, Gustavo Willerslev, Eske Nielsen, Rasmus |
author_facet | Malaspinas, Anna-Sapfo Tange, Ole Moreno-Mayar, José Víctor Rasmussen, Morten DeGiorgio, Michael Wang, Yong Valdiosera, Cristina E. Politis, Gustavo Willerslev, Eske Nielsen, Rasmus |
author_sort | Malaspinas, Anna-Sapfo |
collection | PubMed |
description | Summary: We present bammds, a practical tool that allows visualization of samples sequenced by second-generation sequencing when compared with a reference panel of individuals (usually genotypes) using a multidimensional scaling algorithm. Our tool is aimed at determining the ancestry of unknown samples—typical of ancient DNA data—particularly when only low amounts of data are available for those samples. Availability and implementation: The software package is available under GNU General Public License v3 and is freely available together with test datasets https://savannah.nongnu.org/projects/bammds/. It is using R (http://www.r-project.org/), parallel (http://www.gnu.org/software/parallel/), samtools (https://github.com/samtools/samtools). Contact: bammds-users@nongnu.org Supplementary information: Supplementary data are available at Bioinformatics online. |
format | Online Article Text |
id | pubmed-4184259 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-41842592014-10-07 bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) Malaspinas, Anna-Sapfo Tange, Ole Moreno-Mayar, José Víctor Rasmussen, Morten DeGiorgio, Michael Wang, Yong Valdiosera, Cristina E. Politis, Gustavo Willerslev, Eske Nielsen, Rasmus Bioinformatics Applications Notes Summary: We present bammds, a practical tool that allows visualization of samples sequenced by second-generation sequencing when compared with a reference panel of individuals (usually genotypes) using a multidimensional scaling algorithm. Our tool is aimed at determining the ancestry of unknown samples—typical of ancient DNA data—particularly when only low amounts of data are available for those samples. Availability and implementation: The software package is available under GNU General Public License v3 and is freely available together with test datasets https://savannah.nongnu.org/projects/bammds/. It is using R (http://www.r-project.org/), parallel (http://www.gnu.org/software/parallel/), samtools (https://github.com/samtools/samtools). Contact: bammds-users@nongnu.org Supplementary information: Supplementary data are available at Bioinformatics online. Oxford University Press 2014-10-15 2014-06-28 /pmc/articles/PMC4184259/ /pubmed/24974206 http://dx.doi.org/10.1093/bioinformatics/btu410 Text en © The Author 2014. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Applications Notes Malaspinas, Anna-Sapfo Tange, Ole Moreno-Mayar, José Víctor Rasmussen, Morten DeGiorgio, Michael Wang, Yong Valdiosera, Cristina E. Politis, Gustavo Willerslev, Eske Nielsen, Rasmus bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) |
title | bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) |
title_full | bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) |
title_fullStr | bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) |
title_full_unstemmed | bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) |
title_short | bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) |
title_sort | bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (mds) |
topic | Applications Notes |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184259/ https://www.ncbi.nlm.nih.gov/pubmed/24974206 http://dx.doi.org/10.1093/bioinformatics/btu410 |
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