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bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)

Summary: We present bammds, a practical tool that allows visualization of samples sequenced by second-generation sequencing when compared with a reference panel of individuals (usually genotypes) using a multidimensional scaling algorithm. Our tool is aimed at determining the ancestry of unknown sam...

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Autores principales: Malaspinas, Anna-Sapfo, Tange, Ole, Moreno-Mayar, José Víctor, Rasmussen, Morten, DeGiorgio, Michael, Wang, Yong, Valdiosera, Cristina E., Politis, Gustavo, Willerslev, Eske, Nielsen, Rasmus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184259/
https://www.ncbi.nlm.nih.gov/pubmed/24974206
http://dx.doi.org/10.1093/bioinformatics/btu410
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author Malaspinas, Anna-Sapfo
Tange, Ole
Moreno-Mayar, José Víctor
Rasmussen, Morten
DeGiorgio, Michael
Wang, Yong
Valdiosera, Cristina E.
Politis, Gustavo
Willerslev, Eske
Nielsen, Rasmus
author_facet Malaspinas, Anna-Sapfo
Tange, Ole
Moreno-Mayar, José Víctor
Rasmussen, Morten
DeGiorgio, Michael
Wang, Yong
Valdiosera, Cristina E.
Politis, Gustavo
Willerslev, Eske
Nielsen, Rasmus
author_sort Malaspinas, Anna-Sapfo
collection PubMed
description Summary: We present bammds, a practical tool that allows visualization of samples sequenced by second-generation sequencing when compared with a reference panel of individuals (usually genotypes) using a multidimensional scaling algorithm. Our tool is aimed at determining the ancestry of unknown samples—typical of ancient DNA data—particularly when only low amounts of data are available for those samples. Availability and implementation: The software package is available under GNU General Public License v3 and is freely available together with test datasets https://savannah.nongnu.org/projects/bammds/. It is using R (http://www.r-project.org/), parallel (http://www.gnu.org/software/parallel/), samtools (https://github.com/samtools/samtools). Contact: bammds-users@nongnu.org Supplementary information: Supplementary data are available at Bioinformatics online.
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spelling pubmed-41842592014-10-07 bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS) Malaspinas, Anna-Sapfo Tange, Ole Moreno-Mayar, José Víctor Rasmussen, Morten DeGiorgio, Michael Wang, Yong Valdiosera, Cristina E. Politis, Gustavo Willerslev, Eske Nielsen, Rasmus Bioinformatics Applications Notes Summary: We present bammds, a practical tool that allows visualization of samples sequenced by second-generation sequencing when compared with a reference panel of individuals (usually genotypes) using a multidimensional scaling algorithm. Our tool is aimed at determining the ancestry of unknown samples—typical of ancient DNA data—particularly when only low amounts of data are available for those samples. Availability and implementation: The software package is available under GNU General Public License v3 and is freely available together with test datasets https://savannah.nongnu.org/projects/bammds/. It is using R (http://www.r-project.org/), parallel (http://www.gnu.org/software/parallel/), samtools (https://github.com/samtools/samtools). Contact: bammds-users@nongnu.org Supplementary information: Supplementary data are available at Bioinformatics online. Oxford University Press 2014-10-15 2014-06-28 /pmc/articles/PMC4184259/ /pubmed/24974206 http://dx.doi.org/10.1093/bioinformatics/btu410 Text en © The Author 2014. Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Applications Notes
Malaspinas, Anna-Sapfo
Tange, Ole
Moreno-Mayar, José Víctor
Rasmussen, Morten
DeGiorgio, Michael
Wang, Yong
Valdiosera, Cristina E.
Politis, Gustavo
Willerslev, Eske
Nielsen, Rasmus
bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
title bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
title_full bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
title_fullStr bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
title_full_unstemmed bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
title_short bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (MDS)
title_sort bammds: a tool for assessing the ancestry of low-depth whole-genome data using multidimensional scaling (mds)
topic Applications Notes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184259/
https://www.ncbi.nlm.nih.gov/pubmed/24974206
http://dx.doi.org/10.1093/bioinformatics/btu410
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