Evaluation of AMG 076, a potent and selective MCHR1 antagonist, in rodent and primate obesity models

Melanin-concentrating hormone (MCH) regulates food intake through activation of the receptor, MCHR1. We have identified AMG 076 as an orally bioavailable potent and selective small molecule antagonist of MCHR1. In mouse models of obesity, AMG 076 caused a reduction in body weight gain in wild-type (...

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Detalles Bibliográficos
Autores principales: Motani, Alykhan S, Luo, Jian, Liang, Lingming, Mihalic, Jeffrey T, Chen, Xiaoqi, Tang, Liang, Li, Leping, Jaen, Juan, Chen, Jin-Long, Dai, Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184568/
https://www.ncbi.nlm.nih.gov/pubmed/25505557
http://dx.doi.org/10.1002/prp2.3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184568/
https://www.ncbi.nlm.nih.gov/pubmed/25505557
http://dx.doi.org/10.1002/prp2.3

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