Enantioselectivity in the cytochrome P450-dependent conversion of tegafur to 5-fluorouracil in human liver microsomes

Tegafur (FT) is a prodrug of 5-fluorouracil (5-FU) used in cancer chemotherapy, and the bioactivation of FT to 5-FU is mainly catalyzed by cytochrome P450 (CYP) in hepatic microsomes. FT has a chiral center and is a racemate consisting of the enantiomers, R- and S-FT. In the present study, we clarif...

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Detalles Bibliográficos
Autores principales: Yamamiya, Ikuo, Yoshisue, Kunihiro, Ishii, Yuji, Yamada, Hideyuki, Yoshida, Ken-ichiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2013
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184574/
https://www.ncbi.nlm.nih.gov/pubmed/25505563
http://dx.doi.org/10.1002/prp2.9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184574/
https://www.ncbi.nlm.nih.gov/pubmed/25505563
http://dx.doi.org/10.1002/prp2.9

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