From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease

The development of drugs with different pharmacological properties appears to be an innovative therapeutic approach for Alzheimer's disease. In this article, we describe a simple structural modification of AP2238, a first dual function lead, in particular the introduction of the catechol moiety...

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Detalles Bibliográficos
Autores principales: Tarozzi, Andrea, Bartolini, Manuela, Piazzi, Lorna, Valgimigli, Luca, Amorati, Riccardo, Bolondi, Cecilia, Djemil, Alice, Mancini, Francesca, Andrisano, Vincenza, Rampa, Angela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184701/
https://www.ncbi.nlm.nih.gov/pubmed/25505579
http://dx.doi.org/10.1002/prp2.23

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184701/
https://www.ncbi.nlm.nih.gov/pubmed/25505579
http://dx.doi.org/10.1002/prp2.23

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