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From the dual function lead AP2238 to AP2469, a multi-target-directed ligand for the treatment of Alzheimer's disease
The development of drugs with different pharmacological properties appears to be an innovative therapeutic approach for Alzheimer's disease. In this article, we describe a simple structural modification of AP2238, a first dual function lead, in particular the introduction of the catechol moiety...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BlackWell Publishing Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184701/ https://www.ncbi.nlm.nih.gov/pubmed/25505579 http://dx.doi.org/10.1002/prp2.23 |