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Effects of repeated dosing with mechanistically distinct antinociceptive ligands in a rat model of neuropathic spinal cord injury pain

A lack of efficacy of some analgesic drugs has been previously described in rats with neuropathic spinal cord injury (SCI) pain. It has been suggested that repeated dosing in these animals over time may eventually lead to efficacy. However, it is also possible that efficacy may diminish over time wi...

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Detalles Bibliográficos
Autores principales: Hama, Aldric T, Pearson, James P, Sagen, Jacqueline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184706/
https://www.ncbi.nlm.nih.gov/pubmed/25505583
http://dx.doi.org/10.1002/prp2.34