Species differences in sinusoidal and canalicular efflux transport of mycophenolic acid 7-O-glucuronide in sandwich-cultured hepatocytes

Metabolism and sinusoidal/canalicular efflux of mycophenolic acid (MPA) was investigated using sandwich-cultured hepatocytes (SCHs). After applying MPA to SCHs from humans, wild-type rats, and multidrug resistance-associated protein (Mrp) 2-deficient rats, the MPA metabolites 7-O-glucuronide (MPAG)...

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Detalles Bibliográficos
Autores principales: Tetsuka, Kazuhiro, Gerst, Nicolas, Tamura, Kouichi, Masters, Jeffrey N
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BlackWell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184707/
https://www.ncbi.nlm.nih.gov/pubmed/25505584
http://dx.doi.org/10.1002/prp2.35

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184707/
https://www.ncbi.nlm.nih.gov/pubmed/25505584
http://dx.doi.org/10.1002/prp2.35

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