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Orthovanadate-induced vasocontraction is mediated by the activation of Rho-kinase through Src-dependent transactivation of epidermal growth factor receptor
Orthovanadate (OVA), a protein tyrosine phosphatase (PTPase) inhibitor, exerts contractile effects on smooth muscle in a Rho-kinase-dependent manner, but the precise mechanisms are not elucidated. The aim of this study was to determine the potential roles of Src and epidermal growth factor receptor...
Autores principales: | Yayama, Katsutoshi, Sasahara, Tomoya, Ohba, Hisaaki, Funasaka, Ayaka, Okamoto, Hiroshi |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BlackWell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184709/ https://www.ncbi.nlm.nih.gov/pubmed/25505586 http://dx.doi.org/10.1002/prp2.39 |
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