Role of Key TYMS Polymorphisms on Methotrexate Therapeutic Outcome in Portuguese Rheumatoid Arthritis Patients

BACKGROUND: Therapeutic outcome of rheumatoid arthritis (RA) patients treated with methotrexate (MTX) can be modulated by thymidylate synthase (TS) levels, which may be altered by genetic polymorphisms in TS gene (TYMS). This study aims to elucidate the influence of TYMS polymorphisms in MTX therape...

Descripción completa

Detalles Bibliográficos
Autores principales: Lima, Aurea, Seabra, Vítor, Bernardes, Miguel, Azevedo, Rita, Sousa, Hugo, Medeiros, Rui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184792/
https://www.ncbi.nlm.nih.gov/pubmed/25279663
http://dx.doi.org/10.1371/journal.pone.0108165

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184792/
https://www.ncbi.nlm.nih.gov/pubmed/25279663
http://dx.doi.org/10.1371/journal.pone.0108165

Ejemplares similares