Cargando…

Role of Key TYMS Polymorphisms on Methotrexate Therapeutic Outcome in Portuguese Rheumatoid Arthritis Patients

BACKGROUND: Therapeutic outcome of rheumatoid arthritis (RA) patients treated with methotrexate (MTX) can be modulated by thymidylate synthase (TS) levels, which may be altered by genetic polymorphisms in TS gene (TYMS). This study aims to elucidate the influence of TYMS polymorphisms in MTX therape...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lima, Aurea, Seabra, Vítor, Bernardes, Miguel, Azevedo, Rita, Sousa, Hugo, Medeiros, Rui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4184792/ https://www.ncbi.nlm.nih.gov/pubmed/25279663 http://dx.doi.org/10.1371/journal.pone.0108165

Ejemplares similares

Prediction of Methotrexate Clinical Response in Portuguese Rheumatoid Arthritis Patients: Implication of MTHFR rs1801133 and ATIC rs4673993 Polymorphisms
por: Lima, Aurea, et al.
Publicado: (2014)

Pharmacogenomics of Methotrexate Membrane Transport Pathway: Can Clinical Response to Methotrexate in Rheumatoid Arthritis Be Predicted?
por: Lima, Aurea, et al.
Publicado: (2015)

Genetic Polymorphisms of TYMS, MTHFR, ATIC, MTR, and MTRR Are Related to the Outcome of Methotrexate Therapy for Rheumatoid Arthritis in a Chinese Population
por: Lv, Shuang, et al.
Publicado: (2018)

Replication study of polymorphisms associated with response to methotrexate in patients with rheumatoid arthritis
por: López-Rodríguez, Rosario, et al.
Publicado: (2018)

Genetic polymorphisms in key methotrexate pathway genes are associated with response to treatment in rheumatoid arthritis patients
por: Owen, S A, et al.
Publicado: (2012)

Thymidylate synthase gene (TYMS) polymorphisms in sporadic and hereditary breast cancer
por: Junior, José da Silva Nogueira, et al.
Publicado: (2012)

Clinical and Laboratory Associations with Methotrexate Metabolism Gene Polymorphisms in Rheumatoid Arthritis
por: D’Cruz, Leon G., et al.
Publicado: (2020)

Nano Methotrexate versus Methotrexate in Targeting Rheumatoid Arthritis
por: Salem, Heba F., et al.
Publicado: (2022)

Methotrexate alone and methotrexate combined with etanercept in treatment of rheumatoid arthritis
por: Rexhepi, Sylejman, et al.
Publicado: (2012)

Methotrexate Hepatotoxicity in Patients with Rheumatoid Arthritis
por: Sotoudehmanesh, R, et al.
Publicado: (2010)

Adherence to Methotrexate therapy in Rheumatoid Arthritis
por: Arshad, Nasim, et al.
Publicado: (2016)

MTHFR and MTRR Genetic Polymorphism of Methotrexate Therapy Outcomes in Early Rheumatoid Arthritis
por: Zhang, Qian, et al.
Publicado: (2023)

The Impact of COVID-19 Pandemic in Portuguese Cancer Patients: A Retrospective Study
por: Lima, Aurea, et al.
Publicado: (2021)

Correlation between polymorphism of TYMS gene and toxicity response to treatment with 5-fluoruracil and capecitabine
por: Vitello, Stefano, et al.
Publicado: (2020)

Prevalence of methotrexate intolerance in rheumatoid arthritis and psoriatic arthritis
por: Bulatović Ćalasan, Maja, et al.
Publicado: (2013)

Portuguese adaptation and validation of a patient-reported experience measure for patients with rheumatoid arthritis: A protocol study
por: Oliveira, Daniela, et al.
Publicado: (2022)

Genetic Polymorphisms of GGH and ABCC2 Are Associated with Methotrexate Intolerance in Patients with Rheumatoid Arthritis
por: Escudero-Contreras, Alejandro, et al.
Publicado: (2021)

Test Your Memory (TYM) and Test Your Memory for Mild Cognitive Impairment (TYM-MCI): A Review and Update Including Results of Using the TYM Test in a General Neurology Clinic and Using a Telephone Version of the TYM Test
por: Brown, Jeremy M., et al.
Publicado: (2019)

Recommendations for optimizing methotrexate treatment for patients with rheumatoid arthritis
por: Bello, Alfonso E, et al.
Publicado: (2017)

Safety Profile of Methotrexate Therapy in Patients With Rheumatoid Arthritis
por: Mustafa, Syed Hassan, et al.
Publicado: (2022)

Rheumatoid arthritis and Hailey‐Hailey disease treated with methotrexate
por: Mestre, Beatriz, et al.
Publicado: (2022)

Efficacy of etanercept in combination with methotrexate in moderate-to-severe rheumatoid arthritis is not dependent on methotrexate dosage
por: Gallo, G, et al.
Publicado: (2016)

Polymorphisms and Pharmacogenomics for the Clinical Efficacy of Methotrexate in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis
por: Qiu, Qi, et al.
Publicado: (2017)

Polymorphisms and pharmacogenomics for the toxicity of methotrexate monotherapy in patients with rheumatoid arthritis: A systematic review and meta-analysis
por: Qiu, Qi, et al.
Publicado: (2017)

LHC prawdopodobnie ruszy w tym tygodniu
Publicado: (2009)

Effects of low-dose tacrolimus therapy in combination with methotrexate in patients with methotrexate-refractory rheumatoid arthritis
por: Isozaki, Takeo, et al.
Publicado: (2010)

Treatment efficacy and methotrexate-related toxicity in patients with rheumatoid arthritis receiving methotrexate in combination with adalimumab
por: Burmester, Gerd R, et al.
Publicado: (2017)

The pharmacokinetic effect of coadministration of apremilast and methotrexate in individuals with rheumatoid arthritis and psoriatic arthritis
por: Liu, Yong, et al.
Publicado: (2014)

Serum adenosine deaminase in patients with rheumatoid arthritis treated with methotrexate
por: Salesi, Mansour, et al.
Publicado: (2012)

Patient’s experience with subcutaneous and oral methotrexate for the treatment of rheumatoid arthritis
por: Curtis, J. R., et al.
Publicado: (2016)

Remaining Pain in Early Rheumatoid Arthritis Patients Treated With Methotrexate
por: Altawil, Reem, et al.
Publicado: (2016)

Role of methotrexate chronotherapy in collagen-induced rheumatoid arthritis in rats
por: Wang, X., et al.
Publicado: (2016)

Risk Factors Associated with Methotrexate Intolerance in Rheumatoid Arthritis Patients
por: Almalag, Haya, et al.
Publicado: (2020)

Differential DNA methylation correlates with response to methotrexate in rheumatoid arthritis
por: Nair, Nisha, et al.
Publicado: (2020)

Increased Encapsulation Efficiency of Methotrexate in Liposomes for Rheumatoid Arthritis Therapy
por: Guimarães, Diana, et al.
Publicado: (2020)

Etanercept or Methotrexate Withdrawal in Rheumatoid Arthritis Patients in Sustained Remission
por: Curtis, Jeffrey R., et al.
Publicado: (2021)

Molecular signature of methotrexate response among rheumatoid arthritis patients
por: Brynedal, Boel, et al.
Publicado: (2023)

Lymphoproliferative disorder risk after methotrexate treatment for rheumatoid arthritis
por: Tanaka, Keisuke, et al.
Publicado: (2023)

Hypoplastic Myelodysplastic Syndrome: Symptom of Methotrexate Toxicity in Rheumatoid Arthritis
por: Khan, Adil, et al.
Publicado: (2023)

DPYD, TYMS and MTHFR Genes Polymorphism Frequencies in a Series of Turkish Colorectal Cancer Patients
por: Amirfallah, Arsalan, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_hq9g3gfrjkgte8n78ber1d87ga