Cargando…
Common genetic variation in and near the melanocortin 4 receptor gene (MC4R) is associated with body mass index in American Indian adults and children
Six rare functional coding mutations were previously identified in melanocortin 4 receptor (MC4R) in 6,760 American Indians. Individuals heterozygous for one of these mutations become obese while young. We now investigate whether common non-coding variation near MC4R also contributes to obesity. Fif...
Autores principales: | Muller, Yunhua L., Thearle, Marie S., Piaggi, Paolo, Hanson, Robert L., Hoffman, Duncan, Gene, Brittany, Mahkee, Darin, Huang, Ke, Kobes, Sayuko, Votruba, Susanne, Knowler, William C., Bogardus, Clifton, Baier, Leslie J. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Berlin Heidelberg
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185108/ https://www.ncbi.nlm.nih.gov/pubmed/25103139 http://dx.doi.org/10.1007/s00439-014-1477-6 |
Ejemplares similares
-
Common genetic variation in the glucokinase gene (GCK) is associated with type 2 diabetes and rates of carbohydrate oxidation and energy expenditure
por: Muller, Yunhua L., et al.
Publicado: (2014) -
Lower Metabolic Rate in Individuals Heterozygous for Either a Frameshift or a Functional Missense MC4R Variant
por: Krakoff, Jonathan, et al.
Publicado: (2008) -
Greater Impact of Melanocortin-4 Receptor Deficiency on Rates of Growth and Risk of Type 2 Diabetes During Childhood Compared With Adulthood in Pima Indians
por: Thearle, Marie S., et al.
Publicado: (2012) -
Assessing Accuracy of Genotype Imputation in American Indians
por: Malhotra, Alka, et al.
Publicado: (2014) -
Strong Parent-of-Origin Effects in the Association of KCNQ1 Variants With Type 2 Diabetes in American Indians
por: Hanson, Robert L., et al.
Publicado: (2013)