One origin for metallo-β-lactamase activity, or two? An investigation assessing a diverse set of reconstructed ancestral sequences based on a sample of phylogenetic trees

Bacteria use metallo-β-lactamase enzymes to hydrolyse lactam rings found in many antibiotics, rendering them ineffective. Metallo-β-lactamase activity is thought to be polyphyletic, having arisen on more than one occasion within a single functionally diverse homologous superfamily. Since discovery o...

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Detalles Bibliográficos
Autores principales: Alderson, Rosanna G., Barker, Daniel, Mitchell, John B. O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185109/
https://www.ncbi.nlm.nih.gov/pubmed/25185655
http://dx.doi.org/10.1007/s00239-014-9639-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185109/
https://www.ncbi.nlm.nih.gov/pubmed/25185655
http://dx.doi.org/10.1007/s00239-014-9639-7

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