Low expression of Abelson interactor-1 is linked to acquired drug resistance in Bcr-Abl induced leukemia

The basis for persistence of leukemic stem cells in the bone marrow microenvironment (BMME) remains poorly understood. We present evidence that signaling crosstalk between α4 integrin and Abelson interactor-1 (Abi-1) is involved in acquisition of an anchorage-dependent phenotype and drug resistance...

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Detalles Bibliográficos
Autores principales: Chorzalska, Anna, Salloum, Ibrahem, Shafqat, Hammad, Khan, Saad, Marjon, Philip, Treaba, Diana, Schorl, Christoph, Morgan, John, Bryke, Christine R., Falanga, Vincent, Zhao, Thing C., Reagan, John, Winer, Eric, Olszewski, Adam, Al-Homsi, Samer, Kouttab, Nicola, Dubielecka, Patrycja M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185277/
https://www.ncbi.nlm.nih.gov/pubmed/24699303
http://dx.doi.org/10.1038/leu.2014.120

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185277/
https://www.ncbi.nlm.nih.gov/pubmed/24699303
http://dx.doi.org/10.1038/leu.2014.120

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