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Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity
Mediator complex is a molecular hub integrating signaling, transcription factors, and RNA polymerase II (RNAPII) machinery. Mediator MED23 is involved in adipogenesis and smooth muscle cell differentiation, suggesting its role in energy homeostasis. Here, through the generation and analysis of a liv...
Autores principales: | Chu, Yajing, Rosso, Leonardo Gómez, Huang, Ping, Wang, Zhichao, Xu, Yichi, Yao, Xiao, Bao, Menghan, Yan, Jun, Song, Haiyun, Wang, Gang |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185346/ https://www.ncbi.nlm.nih.gov/pubmed/25223702 http://dx.doi.org/10.1038/cr.2014.120 |
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