SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age

L1 retrotransposons are an abundant class of transposable elements which pose a threat to genome stability and may play a role in age-related pathologies such as cancer. Recent evidence indicates that L1s become more active in somatic tissues during the course of aging; the mechanisms underlying thi...

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Detalles Bibliográficos
Autores principales: Van Meter, Michael, Kashyap, Mehr, Rezazadeh, Sarallah, Geneva, Anthony J., Morello, Timothy D., Seluanov, Andrei, Gorbunova, Vera
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185372/
https://www.ncbi.nlm.nih.gov/pubmed/25247314
http://dx.doi.org/10.1038/ncomms6011

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185372/
https://www.ncbi.nlm.nih.gov/pubmed/25247314
http://dx.doi.org/10.1038/ncomms6011

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