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SIRT6 represses LINE1 retrotransposons by ribosylating KAP1 but this repression fails with stress and age
L1 retrotransposons are an abundant class of transposable elements which pose a threat to genome stability and may play a role in age-related pathologies such as cancer. Recent evidence indicates that L1s become more active in somatic tissues during the course of aging; the mechanisms underlying thi...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4185372/ https://www.ncbi.nlm.nih.gov/pubmed/25247314 http://dx.doi.org/10.1038/ncomms6011 |