Characterization of a novel brain barrier ex vivo insect-based P-glycoprotein screening model

In earlier studies insects were proposed as suitable models for vertebrate blood–brain barrier (BBB) permeability prediction and useful in early drug discovery. Here we provide transcriptome and functional data demonstrating the presence of a P-glycoprotein (Pgp) efflux transporter in the brain barr...

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Detalles Bibliográficos
Autores principales: Andersson, Olga, Badisco, Liesbeth, Hansen, Ane Håkansson, Hansen, Steen Honoré, Hellman, Karin, Nielsen, Peter Aadal, Olsen, Line Rørbæk, Verdonck, Rik, Abbott, N Joan, Vanden Broeck, Jozef, Andersson, Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186439/
https://www.ncbi.nlm.nih.gov/pubmed/25505597
http://dx.doi.org/10.1002/prp2.50

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186439/
https://www.ncbi.nlm.nih.gov/pubmed/25505597
http://dx.doi.org/10.1002/prp2.50

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