Analysis of FK506, timcodar (VX-853) and FKBP51 and FKBP52 chaperones in control of glucocorticoid receptor activity and phosphorylation

The immunosuppressive ligand FK506 and the FK506-binding protein FKBP52 are stimulatory to glucocorticoid receptor (GR) activity. Here, we explore the underlying mechanism by comparing GR activity and phosphorylation status in response to FK506 and the novel nonimmunosuppressive ligand timcodar (VX-...

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Detalles Bibliográficos
Autores principales: Hinds, Terry D, Stechschulte, Lance A, Elkhairi, Fadel, Sanchez, Edwin R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186452/
https://www.ncbi.nlm.nih.gov/pubmed/25505617
http://dx.doi.org/10.1002/prp2.76

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186452/
https://www.ncbi.nlm.nih.gov/pubmed/25505617
http://dx.doi.org/10.1002/prp2.76

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