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Investigation of the binding and cleavage characteristics of N1 neuraminidases from avian, seasonal, and pandemic influenza viruses using saturation transfer difference nuclear magnetic resonance
OBJECTIVES: The main function of influenza neuraminidase (NA) involves enzymatic cleavage of sialic acid from the surface of host cells resulting in the release of the newly produced virions from infected cells, as well as aiding the movement of virions through sialylated mucus present in the respir...
Autores principales: | Garcia, Jean-Michel, Lai, Jimmy C C, Haselhorst, Thomas, Choy, Ka Tim, Yen, Hui-Ling, Peiris, Joseph S M, von Itzstein, Mark, Nicholls, John M |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Blackwell Publishing Ltd
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186472/ https://www.ncbi.nlm.nih.gov/pubmed/24118862 http://dx.doi.org/10.1111/irv.12184 |
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