Knockdown of DNA methyltransferase-1 inhibits proliferation and derepresses tumor suppressor genes in myeloma cells

DNA methyltransferases (including DNMT1, DNMT3A and DNMT3B), catalyze the transfer of methyl groups from S-adenosyl-l-methionine to cytosine position 5; this methylation in promoter regions silences gene expression. In addition, DNMT1 plays a critical role in the maintenance of genomic DNA methylati...

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Detalles Bibliográficos
Autores principales: ZHOU, WENWEN, CHEN, HUYING, HONG, XIULI, NIU, XIAOQING, LU, QUANYI
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186563/
https://www.ncbi.nlm.nih.gov/pubmed/25289094
http://dx.doi.org/10.3892/ol.2014.2481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186563/
https://www.ncbi.nlm.nih.gov/pubmed/25289094
http://dx.doi.org/10.3892/ol.2014.2481

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