Oncolytic adenovirus-expressed RNA interference of O(6)-methylguanine DNA methyltransferase activity may enhance the antitumor effects of temozolomide

Temozolomide (TMZ) is an example of an alkylating agent, which are known to be effective anticancer drugs for the treatment of various solid tumors, including glioma and melanoma. TMZ acts predominantly through the mutagenic product O(6)-methylguanine, a cytotoxic DNA lesion. The DNA repair enzyme,...

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Detalles Bibliográficos
Autores principales: CHEN, XIN-JUN, ZHANG, KAI, XIN, YONG, JIANG, GUAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2014
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186622/
https://www.ncbi.nlm.nih.gov/pubmed/25295108
http://dx.doi.org/10.3892/ol.2014.2442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186622/
https://www.ncbi.nlm.nih.gov/pubmed/25295108
http://dx.doi.org/10.3892/ol.2014.2442

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