Elevation of Proteasomal Substrate Levels Sensitizes Cells to Apoptosis Induced by Inhibition of Proteasomal Deubiquitinases

Inhibitors of the catalytic activity of the 20S proteasome are cytotoxic to tumor cells and are currently in clinical use for treatment of multiple myeloma, whilst the deubiquitinase activity associated with the 19S regulatory subunit of the proteasome is also a valid target for anti-cancer drugs. T...

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Detalles Bibliográficos
Autores principales: Sun, Chao, Roboti, Peristera, Puumalainen, Marjo-Riitta, Fryknäs, Mårten, Wang, Xin, D'Arcy, Padraig, Hult, Malin, High, Stephen, Linder, Stig, Swanton, Eileithyia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186810/
https://www.ncbi.nlm.nih.gov/pubmed/25286379
http://dx.doi.org/10.1371/journal.pone.0108839

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186810/
https://www.ncbi.nlm.nih.gov/pubmed/25286379
http://dx.doi.org/10.1371/journal.pone.0108839

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