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Insulitis in human type 1 diabetes: a comparison between patients and animal models
Human type 1 diabetes (T1D) is considered to be an autoimmune disease, with CD8+ T-cell-mediated cytotoxicity being directed against the insulin-producing beta cells, leading to a gradual decrease in beta cell mass and the development of chronic hyperglycemia. The histopathologically defining lesion...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer Berlin Heidelberg
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186970/ https://www.ncbi.nlm.nih.gov/pubmed/25005747 http://dx.doi.org/10.1007/s00281-014-0438-4 |