Selective ligands of estrogen receptor β discovered using pharmacophore mapping and structure-based virtual screening

AIM: To discover novel ligands of estrogen receptor (ER) β using pharmacophore mapping and structure-based screening. METHODS: A computer-aided strategy combining pharmacophore mapping and structure-based screening was used to screen the Maybridge and Enamine databases. Yeast two-hybrid (Y2H) assay...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Lei, Wu, Dang, Bian, Han-ping, Kuang, Guang-lin, Jiang, Jing, Li, Wei-hua, Liu, Gui-xia, Zou, Shi-en, Huang, Jin, Tang, Yun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186986/
https://www.ncbi.nlm.nih.gov/pubmed/25176400
http://dx.doi.org/10.1038/aps.2014.69

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4186986/
https://www.ncbi.nlm.nih.gov/pubmed/25176400
http://dx.doi.org/10.1038/aps.2014.69

Ejemplares similares