Cargando…

CCR5 Inhibition Prevents Cardiac Dysfunction in the SIV/Macaque Model of HIV

BACKGROUND: Diastolic dysfunction is a highly prevalent cardiac abnormality in asymptomatic as well as ART‐treated human immunodeficiency virus (HIV) patients. Although the mechanisms underlying depressed cardiac function remain obscure, diastolic dysfunction in SIV‐infected rhesus macaques is highl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kelly, Kathleen M., Tocchetti, Carlo G., Lyashkov, Alexey, Tarwater, Patrick M., Bedja, Djahida, Graham, David R., Beck, Sarah E., Metcalf Pate, Kelly A., Queen, Suzanne E., Adams, Robert J., Paolocci, Nazareno, Mankowski, Joseph L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Blackwell Publishing Ltd 2014
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4187513/ https://www.ncbi.nlm.nih.gov/pubmed/24695652 http://dx.doi.org/10.1161/JAHA.114.000874

Ejemplares similares

Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain
por: Kelly, Kathleen M., et al.
Publicado: (2013)

Natural Host Genetic Resistance to Lentiviral CNS Disease: A Neuroprotective MHC Class I Allele in SIV-Infected Macaques
por: Mankowski, Joseph L., et al.
Publicado: (2008)

Coordinated Regulation of SIV Replication and Immune Responses in the CNS
por: Witwer, Kenneth W., et al.
Publicado: (2009)

Infectious Virus Persists in CD4(+) T Cells and Macrophages in Antiretroviral Therapy-Suppressed Simian Immunodeficiency Virus-Infected Macaques
por: Abreu, Celina M., et al.
Publicado: (2019)

Myeloid and CD4 T Cells Comprise the Latent Reservoir in Antiretroviral Therapy-Suppressed SIVmac251-Infected Macaques
por: Abreu, Celina M., et al.
Publicado: (2019)

Experimental Treatment of SIV-Infected Macaques via Autograft of CCR5-Disrupted Hematopoietic Stem and Progenitor Cells
por: Yu, Songlin, et al.
Publicado: (2020)

Diabetes Increases the Vulnerability of the Cardiac Mitochondrial Network to Criticality
por: Vetter, Larissa, et al.
Publicado: (2020)

Effect of Single Housing on Innate Immune Activation in Immunodeficiency Virus–Infected Pigtail Macaques (Macaca nemestrina) as a Model of Psychosocial Stress in Acute HIV Infection
por: Castell, Natalie, et al.
Publicado: (2022)

Engineering SIV-resistant macaque hematopoietic stem cells and CD4+ T cells with CCR5-specific zinc-finger nucleases
por: Bonello, G, et al.
Publicado: (2012)

The loss of CCR6+ and CD161+ CD4+ T cell homeostasis contributes to disease progression in SIV-infected rhesus macaques
por: McGary, Colleen S., et al.
Publicado: (2017)

SIV replication is directly downregulated by four antiviral miRNAs
por: Sisk, Jeanne M, et al.
Publicado: (2013)

SIV Evolutionary Dynamics in Cynomolgus Macaques during SIV-Mycobacterium tuberculosis Co-Infection
por: Tisthammer, Kaho H., et al.
Publicado: (2021)

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection
por: Hao, Xing Pei, et al.
Publicado: (2015)

Increased neutrophil apoptosis in chronically SIV-infected macaques
por: Elbim, Carole, et al.
Publicado: (2009)

MHC and KIR Polymorphisms in Rhesus Macaque SIV Infection
por: Walter, Lutz, et al.
Publicado: (2015)

Phylogeny and History of the Lost SIV from Crab-Eating Macaques: SIVmfa
por: McCarthy, Kevin R., et al.
Publicado: (2016)

Transduction of SIV-Specific TCR Genes into Rhesus Macaque CD8(+) T Cells Conveys the Ability to Suppress SIV Replication
por: Barsov, Eugene V., et al.
Publicado: (2011)

Experimental Microbial Dysbiosis Does Not Promote Disease Progression in SIV-Infected Macaques
por: Ortiz, Alexandra M., et al.
Publicado: (2018)

IL-2 immunotherapy in chronically SIV-infected Rhesus Macaques
por: Garibal, Julie, et al.
Publicado: (2012)

SIV Infection Facilitates Mycobacterium tuberculosis Infection of Rhesus Macaques
por: Guo, Ming, et al.
Publicado: (2017)

Hypothetical endogenous SIV-like antigens in Mauritian cynomolgus macaques
por: Li, Hongzhao, et al.
Publicado: (2018)

Rhesus macaque IFITM3 gene polymorphisms and SIV infection
por: Winkler, Michael, et al.
Publicado: (2017)

Cynomolgus macaque IL37 polymorphism and control of SIV infection
por: Shiina, Takashi, et al.
Publicado: (2019)

Early Emergence and Selection of a SIV-LTR C/EBP Site Variant in SIV-Infected Macaques That Increases Virus Infectivity
por: Ravimohan, Shruthi, et al.
Publicado: (2012)

Correction: Transduction of SIV-Specific TCR Genes into Rhesus Macaque CD8(+) T Cells Conveys the Ability to Suppress SIV Replication
por: Barsov, Eugene V., et al.
Publicado: (2018)

Collapse of Cytolytic Potential in SIV-Specific CD8+ T Cells Following Acute SIV Infection in Rhesus Macaques
por: Roberts, Emily R., et al.
Publicado: (2016)

Correction: Early Emergence and Selection of a SIV-LTR C/EBP Site Variant in SIV-Infected Macaques That Increases Virus Infectivity
por: Ravimohan, Shruthi, et al.
Publicado: (2013)

Loss and regain of SIV control upon CD8+ cell depletion in vivo in SIV-controller macaques is not associated with efficient SIV specific CD8+ T-cells
por: Hamimi, C, et al.
Publicado: (2012)

Suppression of SIV-specific CD4(+) T cells by infant but not adult macaque regulatory T cells: implications for SIV disease progression
por: Hartigan-O'Connor, Dennis J., et al.
Publicado: (2007)

Protection of Macaques with Diverse MHC Genotypes against a Heterologous SIV by Vaccination with a Deglycosylated Live-Attenuated SIV
por: Sugimoto, Chie, et al.
Publicado: (2010)

A recombinant attenuated Mycobacterium tuberculosis-SIV combination vaccine is safe and immunogenic in immunocompromised, SIV-infected infant macaques
por: Jensen, K, et al.
Publicado: (2012)

Antimicrobial prophylaxis does not improve post-surgical outcomes in SIV/SHIV-uninfected or SIV/SHIV-infected macaques (Macaca mulatta and Macaca fascicularis) based on a retrospective analysis
por: Moats, Cassandra, et al.
Publicado: (2022)

Macaques vaccinated with live-attenuated SIV control replication of heterologous virus
por: Reynolds, Matthew R., et al.
Publicado: (2008)

Comparison of Influenza and SIV Specific CD8 T Cell Responses in Macaques
por: Jegaskanda, Sinthujan, et al.
Publicado: (2012)

P19-24. Evaluation of recombinant influenza-SIV vaccines in macaques
por: Stambas, J, et al.
Publicado: (2009)

Early Loss of Splenic Tfh Cells in SIV-Infected Rhesus Macaques
por: Moukambi, Félicien, et al.
Publicado: (2015)

Natural and cross-inducible anti-SIV antibodies in Mauritian cynomolgus macaques
por: Li, Hongzhao, et al.
Publicado: (2017)

The role of MHC class I gene products in SIV infection of macaques
por: Silver, Zachary A., et al.
Publicado: (2017)

Characterization of Nef expression in different brain regions of SIV-infected macaques
por: Yarandi, Shadan S., et al.
Publicado: (2020)

Vaccine plus microbicide effective in preventing vaginal SIV transmission in macaques
por: Rahman, Mohammad Arif, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_cpjcbfv13lb8mo9r2nmfv0gdof