Visualization of a substrate‐induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O‐acetylesterase reveals mechanistic conservation in SGNH esterase family members

Peptidoglycan O‐acetylesterase (Ape1), which is required for host survival in Neisseria sp., belongs to the diverse SGNH hydrolase superfamily, which includes important viral and bacterial virulence factors. Here, multi‐domain crystal structures of Ape1 with an SGNH catalytic domain and a newly iden...

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Detalles Bibliográficos
Autores principales: Williams, Allison H., Veyrier, Frédéric J., Bonis, Mathilde, Michaud, Yann, Raynal, Bertrand, Taha, Muhamed‐Kheir, White, Stephen W., Haouz, Ahmed, Boneca, Ivo G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188005/
https://www.ncbi.nlm.nih.gov/pubmed/25286847
http://dx.doi.org/10.1107/S1399004714016770

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188005/
https://www.ncbi.nlm.nih.gov/pubmed/25286847
http://dx.doi.org/10.1107/S1399004714016770

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