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Visualization of a substrate‐induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O‐acetylesterase reveals mechanistic conservation in SGNH esterase family members
Peptidoglycan O‐acetylesterase (Ape1), which is required for host survival in Neisseria sp., belongs to the diverse SGNH hydrolase superfamily, which includes important viral and bacterial virulence factors. Here, multi‐domain crystal structures of Ape1 with an SGNH catalytic domain and a newly iden...
Autores principales: | Williams, Allison H., Veyrier, Frédéric J., Bonis, Mathilde, Michaud, Yann, Raynal, Bertrand, Taha, Muhamed‐Kheir, White, Stephen W., Haouz, Ahmed, Boneca, Ivo G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188005/ https://www.ncbi.nlm.nih.gov/pubmed/25286847 http://dx.doi.org/10.1107/S1399004714016770 |
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