Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex

The structural characterization of the insulin–insulin receptor (IR) interaction still lacks the conformation of the crucial B21–B30 insulin region, which must be different from that in its storage forms to ensure effective receptor binding. Here, it is shown that insulin analogues modified by natur...

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Detalles Bibliográficos
Autores principales: Žáková, Lenka, Kletvíková, Emília, Lepšík, Martin, Collinsová, Michaela, Watson, Christopher J., Turkenburg, Johan P., Jiráček, Jiří, Brzozowski, Andrzej M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Union of Crystallography 2014
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188015/
https://www.ncbi.nlm.nih.gov/pubmed/25286859
http://dx.doi.org/10.1107/S1399004714017775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188015/
https://www.ncbi.nlm.nih.gov/pubmed/25286859
http://dx.doi.org/10.1107/S1399004714017775

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