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Human insulin analogues modified at the B26 site reveal a hormone conformation that is undetected in the receptor complex
The structural characterization of the insulin–insulin receptor (IR) interaction still lacks the conformation of the crucial B21–B30 insulin region, which must be different from that in its storage forms to ensure effective receptor binding. Here, it is shown that insulin analogues modified by natur...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
International Union of Crystallography
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4188015/ https://www.ncbi.nlm.nih.gov/pubmed/25286859 http://dx.doi.org/10.1107/S1399004714017775 |